Explain to patients and caregivers that naloxone’s effects are temporary, and that they must call 911 or get emergency medical help right away in all cases of known or suspected opioid overdose, even if naloxone is administered. Repeat administration may be necessary, particularly for overdose involving buprenorphine, because naloxone is often not effective at the doses available for patient access . Table 4 shows the injection site-related adverse events reported by ≥2 subjects in the Phase 3 studies. Most injection site adverse drug reactions were of mild to moderate severity, with one report of severe injection site pruritus.
However, the plasma concentrations of buprenorphine and norbuprenorphine resulting from therapeutic SUBLOCADE doses are not expected to significantly affect metabolism of other co-medications. The effects of buprenorphine may be dependent on the route of administration. A study assessing buprenorphine exposure 22 to 38 months following the last SUBLOCADE injection indicated that buprenorphine could potentially be detected in plasma and urine over that time period. Concentrations in urine were more variable than in plasma and generally higher depending on the test used drug treatment centers. Hence, it is expected that buprenorphine will be detected in patients for a longer time in urine than in plasma.
What are Sublocade’s side effects?
- It’s approved by the Food and Drug Administration to treat moderate to severe opioid use disorder in people who received buprenorphine products in the past.
- Talk with your doctor about which other treatments are better choices for you.
- Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet.
So, ask your doctor when it’s safe to drink alcohol after your Sublocade treatment has stopped. Because of this, Sublocade must not be injected into a vein . It’s only given as an injection under your skin by trained healthcare professionals. Your doctor may recommend that you have naloxone on hand If you’re at risk of opioid overdose while taking Sublocade. But a person still needs emergency medical attention, even after they receive Narcan. And remember, Sublocade’s effect in your body lasts for weeks to even months after you stop taking the medication.
What should I know about Sublocade vs. Suboxone?
Ask your doctor for more information about this program and how you will receive your medication. For this reason, Sublocade should be injected only under your skin alcoholism and the blame cycle and only by a healthcare professional. Having your injections managed by a healthcare professional helps reduce the risk of the drug being injected incorrectly.
Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. It’s important to talk with your doctor about what to do if you have withdrawal symptoms. The American Society of Addiction Medicine recommends buprenorphine as a treatment for opioid use disorder. The buprenorphine in Sublocade is part of a class of drugs called partial opioid agonists.
Alcohol use with Sublocade
With opioid use disorder, your body and mind depend on and crave opioid drugs. They include prescription pain relievers such as morphine, fentanyl, oxycodone, and tramadol, and illegal drugs such as heroin. However, you should avoid taking should you go back to rehab after a relapse opioids to relieve pain whenever possible. Opioids can increase your risk for respiratory depression , loss of consciousness, and death. Opioids can also be less effective than usual at relieving pain if you’re taking Sublocade.
These include acetaminophen and anti-inflammatories such as ibuprofen. Liver damage can also reveal itself by releasing certain liver enzymes into your blood. In a clinical study, up to 12.4% of people who took Sublocade had high levels of these enzymes in their blood. In a clinical study, sleepiness was reported in 4.9% of people who took 300 mg of Sublocade, followed by 100 mg of Sublocade once a month. Sleepiness occurred in 2% of people who took 300 mg of Sublocade throughout the study. Then your doctor may switch you to Sublocade, which is used for maintenance treatment.
If you’re receiving Sublocade during pregnancy, it’s possible that your child may develop physical dependence on the drug. This means they may be born with a condition called neonatal opioid withdrawal syndrome and require treatment for opioid withdrawal at birth. Based on two studies in 13 lactating women maintained on buprenorphine treatment, buprenorphine and its metabolite norbuprenorphine are present in low levels in human milk and infant urine. Available data have not shown adverse reactions in breastfed infants. Caution should be exercised when SUBLOCADE is administered to a nursing woman.
So it may be safe to receive Sublocade if you have a mild liver problem. Your doctor can help determine whether your liver problem is mild, moderate, or severe. Because of this, it’s possible to have mild withdrawal symptoms after stopping treatment with Sublocade. And these symptoms may not show up until a few weeks or months after your last injection. It’s approved by the Food and Drug Administration to treat moderate to severe opioid use disorder in people who received buprenorphine products in the past.
What should be considered before taking Sublocade?
But keep in mind that what you’ll pay for either drug will depend on your treatment plan, your health insurance, and the pharmacy you use. It may also depend on the cost of the visit to your healthcare provider to receive doses of Sublocade or Suboxone. Under most circumstances, you should avoid taking any opioids to relieve pain while you’re using Sublocade or Suboxone. Taking opioids while receiving these medications can raise your risk for respiratory depression , which can be fatal. Sublocade and Suboxone both contain the active drug buprenorphine. So treatment with both medications at once could increase the risk of side effects.
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The most common signs and symptoms include rashes, hives, and pruritus. A history of hypersensitivity to buprenorphine is a contraindication to the use of SUBLOCADE . Patients who elect to discontinue treatment with SUBLOCADE should be monitored for withdrawal signs and symptoms. Consider transmucosal buprenorphine if needed to treat withdrawal after discontinuing SUBLOCADE. As a routine part of orientation to buprenorphine treatment, educate patients about the risks of concomitant use of benzodiazepines, sedatives, opioid analgesics, and alcohol. SUBLOCADE contains buprenorphine, a Schedule III controlled substance that can be abused in a manner similar to other opioids.
Your SUBLOCADE injection will only be given to you by a certified healthcare provider. Its major metabolite is norbuprenorphine, which is further transformed to its glucuronidated form. The majority of metabolites are excreted in the feces and a small amount in the urine. The following information is provided for clinicians and other healthcare professionals. If you’ve ever had an allergic reaction to buprenorphine , you shouldn’t take Sublocade.
This mass will slowly break down over the next month, steadily releasing the drug into your bloodstream. An opioid is a powerful type of drug often used to treat pain. Opioids include prescription pain relievers such as oxycodone, fentanyl, hydromorphone, and tramadol, and illegal drugs such as heroin.
However, wide variation can be seen in isolated measurements from individual subjects, shown in the figure below. For comparison, stabilization doses of SL buprenorphine in Week 0 failed to provide full blockade to 18 mg of HM. Complete blockade continued throughout the 8 weeks of observation that followed the 2nd SUBLOCADE injection. The opioid blockade study evaluated why alcohol disrupts your sleep the blockade of subjective opioid effects, PK and safety of SC injections of SUBLOCADE in 39 subjects with OUD (not treatment-seeking). In subjects with HCV infection but no sign of hepatic impairment, the changes in the mean Cmax, AUC0-last, and half-life values of buprenorphine were not clinically significant in comparison to healthy subjects without HCV infection.
Sublocade and Suboxone are both brand-name prescription drugs. I was also like you but was skipping days and forgetting to dose so I talked to my doctor and he agreed to do the 100 and I went two months then another 100 then off. You should not drink alcoholor take prescription or over-the-counter medicines that contain alcohol during treatment with SUBLOCADE, because this can lead to loss of consciousness or even death.
No accounts of subjects removing or attempting to remove the depot after administration of SUBLOCADE were reported in premarketing studies. SUBLOCADE is distributed through a restricted distribution system, which is intended to prevent the direct distribution to a patient. SUBLOCADE should only be dispensed directly to a healthcare provider for administration by a healthcare provider. It is supplied in prefilled syringes and is intended for administration only by subcutaneous injection by a healthcare provider. The entire contents of the prefilled syringe should be administered.
Advise patients that because of the risk of serious harm or death due to intravenous self-administration, SUBLOCADE is available only through a restricted program called the SUBLOCADE REMS Program. Healthcare settings and pharmacies are certified and only dispense SUBLOCADE directly to a healthcare provider for administration by healthcare providers . Because buprenorphine levels cannot be rapidly decreased, patients with pre-existing moderate to severe hepatic impairment are not candidates for treatment with SUBLOCADE. Verify that patients have tolerated and are dose adjusted on transmucosal buprenorphine before subcutaneously injecting SUBLOCADE.
You may have a rash, hives, swelling of your face, wheezing, low blood pressure, or loss of consciousness. Call your healthcare provider or get emergency help right away. First, I’m gonna suggest that the top 5 star review was written and submitted by the Pharm Rep who sells this medication. The vernacular is straight out of a talking point, “leave behind” marketing piece. I received my first shot in February and it was a roller coaster until I finally surrendered and went back to the Sub Film Strips for this month. The potential for diversion and misuse is minimized by the Sublocade Risk Evaluation and Mitigation Strategy Program .